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Application of vitamin E in skin diseases

Date:Mar 12, 2021

Although the research on vitamin E has been more than half a century, there is still insufficient evidence for vitamin E to treat specific skin diseases. In many small trials and cases, we have used vitamin E to treat yellow nail syndrome, vibration disease, bullous epidermolysis, cancer prevention, claudication, skin ulcers, collagen synthesis and wound healing. Obviously, vitamin E is not a drug, so there is a lack of placebo-controlled studies for these diseases. However, in the field of skin care, including cosmeceuticals, there is a large amount of experimental evidence on photoprotection.

Vitamin E

Although there are private reports that topical use of vitamin E can prevent scars, the effect of vitamin E on scar formation is still uncertain. Two controlled studies did not show that topical vitamin E can prevent scar formation. However, it is not clear to what extent the stability and formulation of topical vitamin E have affected the results of these studies.

Studies with diabetic mice show that oxidative stress also affects the healing of diabetic wounds, and topical vitamin E can significantly improve wound healing.

Recently, tsourelie-nikita et al. conducted a clinical single-blind placebo-controlled study in which 96 patients with atopic dermatitis received placebo or oral vitamin E (400 IE/day) for 8 months. They found that atopic dermatitis was improved and relieved, and the serum IgE level in the vitamin E treatment group dropped by 62%. Correlation experiments between alpha-tocopherol intake, IgE level and clinical manifestations of atopic dermatitis indicate that oral vitamin E may be a good adjuvant treatment for atopic dermatitis.

Another multi-clinical double-blind study showed that the use of topical vitamins E and C can significantly improve melasma and pigmented contact dermatitis lesions, and the combined use of vitamins E and C is significantly better than the single vitamin treatment group. In addition to the commonly used hydroquinone and sunscreen, topical formulations containing vitamins C and E for decolorization seem to be safe and effective. In addition, there is evidence that oxidative stress is involved in the pathophysiology of melanoma and non-melanoma cancer. Vitamin E slows the growth of melanoma by promoting tumor cell apoptosis and inhibiting vegf-mediated angiogenesis. Although these and other encouraging results have been achieved in terms of the beneficial clinical effects of vitamin E, further studies in the form of well-designed controlled trials are still needed to clarify the effects of vitamin E and its derivatives in the above and Further role in skin diseases.